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Vet Select ©
Skin-eze Spray 8 oz.
    Skin-eze Spray 8 oz.
    • Success Stories
    • How it Works
    • Ingredients
    • Dosage & Directions
    • FAQ
    • Additional Information
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    Vet Select ©

    Skin-eze Spray 8 oz.

    Great to use between bathing for relief from itching and scratching due to sores, hot spots., etc. Spray directly on red, raw skin - ears, paws, etc. Exotic, natural blend of essential oils and homeopathic tinctures in an orange oil base.
    Save $2.24/each when you purchase 3 or more!
    Skin-eze Spray 8 oz.
    $21.99
    Total: $21.99
    Add to Cart

    Looking For A More Comprehensive Treatment?

    Shop Our Other Skin-eze Products

     
    Special Full Treatment Skin Pack
    Topical Treatment Pack
    Buy Pack & Save $8.23

    Includes:

    • Skin-eze O3 Oil 1 oz.
    • Skin-eze Shampoo 8 oz.
    • Skin-eze Spray 8 oz.
    $73.75
    Skin-eze Shampoo 8 oz.
    Save $2.24/each when you purchase 3 or more!
    $21.99
    Skin-eze O3 Oil 1 oz.
    Save $3.01/each when you purchase 3 or more!
    $38.00
     
    Skin-eze Herbal Capsules & Tablets
    Grand Total: $21.99

    Success Stories

    I ordered your products and 10 weeks later she is much better.

    Read More

    At a Glance

    • Spray directly on red, raw skin
    • Made from an exotic blend of essential oils and homeopathic mother tinctures in an orange oil base
    • Use with Skin-eze herbal supplement and Skin-eze shampoo for best results

    Benefits Include

    • Helps relieve itching and scratching due to sores, hot spots, etc.
    • Helps to heal sores, scabs and infection that can result from constant itching and scratching
    • Helps reduce pet dander and allergic reactions in owners
    • Deodorizes bad skin smell
    • Helps repel and control fleas, ticks and mosquitoes safely and naturally

    Success Stories

    What our customers are saying about how Skin-eze Spray 8 oz. has helped their pet's overcome their discomfort.

    5 Stars

    I have a Chocolate Cocker Spaniel named Hershey. Last fall she started getting hotspots and a bad yeast infection on her ears. I have tried Benedryl, steroids and everything else. She had lost almost all of her hair when I found your site early June. I ordered your products and 10 weeks later she is much better. She still itches some which I think may be more habit than anything at this point. Her hair is coming back in. Granted it's a slow process but she looks so much better. I've enclosed before and after pics along with my sincerest gratitude.

    Doris

    5 Stars

    I've been using Skin-eze Spray and Shampoo for flea control, and am so happy to have found natural products that are safe. I have been using the shampoo weekly, and the spray daily. The shampoo kills fleas, and the spray works great as a flea repellent. I especially like not having to rely on chemicals and nasty topicals to control fleas. And it's great to be able to bathe Rocky as often as I want without worrying about washing off the chemicals I now have a sweet smelling pooch again.

    Shirley M.
    Edgewood, NM

    5 Stars

    Dear Sirs,


    I have a precious little 9 year old Shitzsu named Gizmo. I am single and have no children, so him and his health are very important to me. I have tried for over a year to find something that would eliminate his dry, itchy skin condition. No shampoo, conditioners, food addative, sprays or anything else worked. I also had him to the vet numerous times and no success there either. Then, one day, I stumbled on your website, by accident, and thought it would be worth trying. I did order the pills, spray, shampoo and drops from you. I have used your product 4 times and am amazed at the results I've seen already. I will continue using your product and have also told my groomer about your product today and they wanted your website since they have many dogs with the same type of skin conditions that mine had. I will promote you and your fine products to everyone I see that owns a pet.

    Thank you very much,
    Gary B.
    Madison, TN

    5 Stars

    Good Morning!!!


    Gizmo and I would like to thank you sooooo very much for the relief that your product has given both of us. Gizmo is a five year old Yorkie that has had allergy problems all of his little life. He weighs less than six pounds and I was upset at how often we were having to have allergy shots and antibiotics because of the staff infections from his scratching. I was goggling one day and came across your product. I e-mailed you with my concerns and was still skeptical but decided what the heck I have tried everything else from pills to shampoos to food I might as well try this since it was all natural. Thank goodness I did. I purchased the whole package. Gizmo decided he would not take the pills but It didn't really matter because after the first week of baths he felt better. We are entering his worst allergy time of year, but I am not worried now for the first time in five years. It has been over a month since we started with your product and he is happy and I am very happy. I am writing this because I have given your name to my groomer (Colleen Doyle) and I hope you allow her to sell your product so other dogs can have the relief that we have found.

    Thanks again,
    Dennis, Patti, and Gizmo

    5 Stars

    We recently ordered your full skin treatment pack for Sophie, our 6 month old French Bulldog puppy. She has allergies that gave her a tummy rash that was really causing her misery - with constant scratching until she would bleed. After several vists to our Vet, with steroid and cortisone shots - the rash would go away, then return even worse in a few days. We tried every commercial/vet shampoo and pet skin care product out there with very little effect and were at our wits end, with the rash starting to spread to her neck and jowls. Then we came across your web site. We have been using your shampoo, spray, and oil on our puppy for about a week now and the results have been wonderful. Her rash has improved a lot, is shrinking and starting to go away, and the shampoo and spray gives her significant relief from the itching, where nothing else we tried worked. Great products!!!!

    Thank you from:
    Mark and Judi H. (and Sophie)

    5 Stars

    I would like for you to know that our Boxer-Boston Terrier mix, Marley, had such severe skin issues (itching, hot spots, open sores, bright red skin, losing all her hair, miserable all the time, never wanted to play, etc...) that we were gearing ourselves up to have her put her to sleep. We had tried everything and spent SO much money. The vet would only cover up the symptoms with steriods and antibiotics. Once the treatment stopped she'd revert right back to misery. She's not a complainer, she just kept on itching and looking at us with love in her eyes. It was truly heartbreaking.

    Skin-eze is the very first product that has made any difference. I honestly can't believe the difference. Marley's itching much less, her skin is not longer an inflamed color of red (it literally looked like the most severe sunburn ever and probably felt like it too), her hair is growing back, she is running around the yard and wants to play again.

    I am so grateful and thankful that we did not put her to sleep and that she is on her way back to a more normal and comfortable life. Thank you so much. You've actually saved my dog's life.

    Claire R.

    I was at the end of my rope, and I was searching the web for help, my West Highland White Terrier was dying, she had itched he self almost to death. I found your web site and thought how could this help my dog when the vets could not help. I decided to try it and I could not be more pleased, you have given my dog Buttercup a now chance at life, she is back to her old self, playing and having a good time and sleeping through the night without itching.

    Thank You,
    Marge

    My 12 year old female dog was long haired till she was 3 years old. She was 3/4 bald when I started her on you treatment one month ago, She is growing hair again and her skin has improved Can't wait to show her off to the Vet!

    Pal G.

    This is just a short note to tell you, what a success I had with your Skin-eze capsules. We were able to reduce the prescription drug to 1/2 tablet every two days (from 2 every two days) and I'm convinced, that in a few weeks I'm able to reduce this amount to zero. My dog is still on 5 capsules twice a day, and I will have to order more capsules. I'm going to do that in a few weeks when we are in BC.

    Thanks.
    Sonja G.
    British Columbia, Canada

    Just a quick note to say thank you!! My shih tsu constantly licked, scratched until we both went mad. I ordered Skin-eze in December and we both are much happier. The vet kept telling me to use chlortrimeton, it worked sporatically, Skin-eze is truly the answer. If anyone asks, I will certainly recommend you. I am also going to tell my vet.

    George K.

    11 yr old Shihtzu, endless nights of interupted sleep, benedryl did not even come close to calming this dog's itching. We tried it all, short of expensive allergy shots. We had nothing to lose at this point. Skin Eze = $30: no scratching dog = priceless!!!!!! Skeptics, you've got to get this stuff. Our dog stopped itching in 30 minutes of first dose!!!

    Arlene E.

    I just want you to know how much Skin-eze helped my 6-month old Labrador. We adopted him from a Lab Rescue who rescued him from a shelter. He was emaciated and dirty. When we got him, he was scratching and chewing incessantly. I switched from one expensive dogfood to another and even used Salmon oil sprinkled on his food. It was a blessing to find this online. I was stunned as to how quickly this product worked. By his second dose, he has stopped scratching and chewing. Whatever is in these tablets works and I'm glad I didn't have his vet give him steroid shots.

    Thank you for this very fine product!
    Rhonda

    When we got Grommet from the Humane Society, no one warned us that he was an itchy dog. When I described the symptoms to my vet tech sister, she was not encouraging. She cautioned against letting him be on pred long term but said there is very little in the world of medicine that works. Well, we changed his food, bought you product AND started nightly brushing. He slowly got better but not 100%. We really thought it was his food but since your product is an herb, we kept giving it to him. Well, by conicidence, my sister was here the week we ran out of Skin-Eeze tabs. OMG! The poor little feller was so itchy - and so miserable. There is now no question what actually helps and we keep it on hand. He still itches, he's not cured, but he is SO MUCH BETTER taking Skin-Eeze than he is not taking it. Thank you for your product, your honest descriptions, your fast shipping.

    Sincerely,
    Mary, Warren and Grommet.

    Dear Allergic Pet


    I just wanted to let you know about my dog Rio. He has been itching and scratching for two years ever since the local pet groomer nicked his skin (near his private parts) with a trimmer. It was as if suddenly his skin defences had been breached and within a couple of days he was scratching and licking himself into misery.

    We have tried everything. Hundreds and hundreds of pounds have been spent on vets bills and medication. Nothing worked - the poor dog was demented and so was I. I was even thinking that he would have to be put to sleep rather than live this terrible life. Then I thought I would check the Internet to see if there was anything I could find out that my vet didn't know. I found your site.

    Rio has been taking Skin-eze for three weeks now. After 8 days, the itching practically stopped. I say practically as he thinks about having a scratch once or twice a day, but I can stop him by gently asking him not to do it. For 99% of the day he does not even think about it, and there is a complete change in his outlook. He is much happier and seems even to be smiling. He is interested in life again - before he was permanently distracted by his incessant scratching and licking.

    I can't thank you enough.
    Marilyn J.
    Okehampton, Devon, UK

    I have a Chocolate Cocker Spaniel named Hershey. Last fall she started getting hotspots and a bad yeast infection on her ears. I have tried Benedryl, steroids and everything else. She had lost almost all of her hair when I found your site early June. I ordered your products and 10 weeks later she is much better. She still itches some which I think may be more habit than anything at this point. Her hair is coming back in. Granted it's a slow process but she looks so much better. I've enclosed before and after pics along with my sincerest gratitude.

    Doris
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    How it Works

    Herbal Formulas

    These formulations are designed to work extremely well together. By adding additional herbs to a main formulation, one can target specific issues.

    Our herbal formulation for skin and coat issues addresses these problem areas in more than one way. The unique blend works to calm the nervous system. Stress reduction from scratching is addressed. Blood flow and detoxification are affected by various ingredients. Many of the herbs are used for their anti-fungal and anti-bacterial effects. There are also ingredients that promote healthy skin and coat condition.

    All of our herbal formulas are comprised of the highest quality human grade herbs. Our products are processed and bottled in the United States in approved FDA bottling facilities that must adhere to stringent regulations governing laboratory testing for purity.

    Topical Formulas

    Skin-eze shampoo, spray and O3 oil are formulated to work synergistically with Skin-eze capsules or tablets. These are the products that comprise our Special full treatment skin packs. The topical formulas contain a blend of the highest quality essential oils and homeopathic mother tinctures. These topical products are a proprietary blend of exotic substances that bathe and condition the coat and skin (shampoo), help to relieve dry, itchy skin (shampoo and skin spray), help to calm red, inflamed skin (shampoo and skin spray) help heal the skin (shampoo, skin spray and O3 oil), and help promote healing and prevent infection (O3 oil). The Special full treatment skin packs are your best choice for relief from the more serious skin irritations and secondary infections that can result from your pet's scratching due to skin allergies.

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    Ingredients

    Ingredients: Skin-eze Capsules

    Angelica; Arctium; Calamus Gum; Salvia; Rehmannia; Forsythia; Sophora Root; Cicada; Kochia; Schizonepeta; Siler; Licorice in a vegetable capsule.

    Ingredients: Skin-eze Tablets

    Angelica, Arctium, Calamus Gum, Salvia, Rehmannia, Forsythia, Sophora Root, Cicada, Kochia, Schizonepeta, Siler, Licorice. Other (binding) ingredients: Microcrystalline cellulose, Stearic acid, Hydroxypropyl cellulose, Croscarmellose sodium, Magnesium stearate, Silicon dioxide.

    Ingredients: Skin-eze Shampoo

    Deionized water; Citrus oil; Coconut oil; Aloe vera; Cajuput; Bay; Erigeron; Lavender; Roman chamomile; Egyptian geranium; Symphytum; Calendula; Hypericum; Urtica; Arnica.

    Ingredients: Skin-eze Spray

    Deionized water; Citrus oil; Extra virgin olive oil; Aloe vera; Cajuput; Bay; Erigeron; Lavender; Roman chamomile; Egyptian geranium; Symphytum; Calendula; Hypericum; Urtica; Arnica.

    Ingredients: Skin-eze Healing O3 Oil

    Ozonated extra virgin olive oil; Lavender; Roman chamomile; Egyptian geranium; Symphytum; Calendula; Hypericum; Urtica; Arnica.
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    Dosage & Directions

    Skin-eze: How to Use Topical Products (Skin-eze Shampoo, Spray, and O3 Oil):

    Does your pet have any of these symptoms?

    1. 1
      History of ear problems (past or present)?
    2. 2
      Dry, flaky, skin with dandruff?
    3. 3
      Frequent licking of paws?
    4. 4
      Scabs or open sores?
    5. 5
      Nasty or foul odor (stinky ears, etc.)?
    6. 6
      Past history of above symptoms, but these symptoms subside when the dog is on steroids (prednisone, etc.), and come back soon after the steroids are discontinued?

    These cases will benefit by Skin-eze tabs or capsules. However, if your pet has any of the above symptoms, he may have a more extreme case that will require extra help. We recommend our Special Full Treatment Skin Pack for your pet, which includes our Skin-eze tabs or capsules, Skin-eze Magic Herbal Shampoo, Skin-eze Magic Herbal Skin Spray, and Skin-eze Healing O3 Oil. These products should be used as follows:

    1. 1
      Bathe daily with Skin-eze Magic Herbal Shampoo for first 3 or 4 (increase to up to 7 days if symptoms persist); if this is not possible due to size of pet, try spot bathing the affected areas). Bathe two times per week thereafter until the dog is completely itch free. Skin-eze Shampoo with conditioner is natural and safe to use daily, and will not dry the coat. Also, it works great as a whitener on discolored hair.
    2. 2
      If there is a problem with the ears, use Skin-eze Healing O3 Oil in ears (two drops 1-2 times daily as needed). Also, use Skin-eze shampoo around the outside of the ears when bathing. Skin-eze Magic Herbal skin spray can also be used - one spray in the ear and around the outside area of the ear (some pets do better with the O3 oil in the ears, while others do better using the Skin spray for the ears).
    3. 3
      Use Skin-eze Magic Herbal Skin Spray directly on any itchy area or hot spot in between bathing.
    4. 4
      Use Skin-eze Healing O3 Oil on any open sores on the body to help heal the skin and prevent infection.
    5. 5
      Use Skin-eze (capsules or tabs) two times daily. See Skin-eze suggested Dosage.

    Some pets will show improvement within the first 3 to 7 days. More extreme cases could take longer. It is not uncommon for us to hear comments like "I didn't think Skin-eze was working until about the third or fourth week, then my dog started to improve dramatically".

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    FAQ

    Q: How do I determine the proper dosage to give my pet? See Skin-eze Suggested Dosage
    A: The dose is determined by the size of the pet and the severity of the itching. A small pet that is mildly itchy might start with two tabs or capsules, two times daily. The same size pet with severe itchy skin might need 3-4 tabs, two times daily. A large pet that is mildly itchy might start with 4 tabs, two times daily. The same pet with severe itchy skin might need 6 tabs, two times daily. Once you determine the starting dose, continue with it and see how it goes. If the itching is less, but has not been eliminated completely, then increase the dosage.
    Q: Can I overdose my pet on Skin-eze? See Skin-eze Suggested Dosage
    A: A. No, not as long as you stay within the recommended dosing guidelines (an exception may be that a very large pet - 100# or more, may need to dose a bit higher). This is an all-natural, herbal combination found to be safe and, generally, without serious side effects. Once the itching is completely under control, you'll want to try to find the minimum dose necessary to control the symptoms (itching). Once the pet is comfortable and itch free for a week or two, you might want to gradually reduce the dose (in other words, if you were giving 3 tabs twice daily, go to 2 tabs twice daily to see if this dose will be adequate to control itching). If the itching increases, you'll know that you will need to go back up to the original dose. Of course, you can always call our Customer Service representative for help if necessary.
    Q: Can I stop giving my pet the drugs my vet prescribed for itching?
    A: This is a decision that you and/or your veterinarian will have to make. We can offer you the following guidelines. It is usually best to not make any changes in current treatment protocol until you have started using the Skin-eze products and your pet is 'itch free' for a week or two. Many of the drugs given for allergies (itchy skin) can have harmful side effects. Generally speaking, your pet would be better off without these drugs if at all possible. Just remember that steroids must be reduced gradually, so you might want to consult your veterinarian on how best to do this.
    Q: What is the difference between Skin-eze tabs and Skin-eze capsules?
    A: Skin-eze tabs and capsules both contain the same active ingredients. Capsules can be hidden easily in soft food, and most pets don't notice them in the food because the capsule is soft. If your pet or cat is small (12# or under), you might find it easier to administer the tablets, which can be cut into smaller pieces with a pill cutter.
    Q: What if my pet won't eat the tabs or capsules?
    A: Some pets will eat the tabs as treats. If your pet is a picky eater, you will need to find creative ways to get him to eat the tabs or caps. One trick that works well is to soften a thin piece of cheese in the microwave, then wrap the sticky cheese all around the tab or the capsule (most pets will just wolf it down this way). Another option is to hide the tab or capsule in a small meatball of canned food (pet food or even canned cat food - most pets LOVE canned cat food due to its high protein content). Of course, you can always try wrapping the tab or capsule in a thin slice of lunch meat, or even putting peanut butter on it. If your pet is REALLY finicky, try giving him two bites of lunch meat with nothing in it, then sneak in the tab or capsule on the third and subsequent bites (or between bread)! Also, the tabs can be crushed up and hidden in soft food. However, it is best to try and hide the entire capsule or tablet, or a smaller piece of tablet, in some type of food, because they have no odor when given whole and your pet is less likely to reject the product due to taste or smell. Go to this link for more suggestions: Directions.
    Q: My pet has itchy ears that have become infected. He sometimes has a foul odor, and licks his paws frequently. Some of these pets have chronic ear problems or scabs on their face. Sometimes the skin is dry and flaky. Will Skin-eze help?
    A: Yes, there is a good chance that Skin-eze will help. However, on cases like the ones described above, follow the following regimen for best results. Bathe your pet with Skin-eze all natural, herbal shampoo daily for 5-6 days. This is VERY important, in order to speed up the healing process for more immediate relief. After that, continue to bathe twice weekly thereafter. Treat the ears with Skin-eze Oil O3 - put two drops in ears one to two times daily. If the pet has any lesions or sores on the skin, use the Skin-eze Oil O3 or Skin-eze Spray on those areas, too. In addition, use the Skin-eze tabs or capsules as directed above for long term, systemic relief of itchy skin caused by allergies. This will help prevent a recurrence of the scratching that caused the surface damage to the skin.
    Q: My pet has red hot spots. What should I use on that?
    A: In addition to the Skin-eze tabs or capsules, use Skin-eze Spray to cool the skin and give topical relief to itchy skin.
    Q: Is Skin-eze guaranteed to work?
    A: No. There is no product that will work on 100% of all cases (this is why huge drug companies do not guarantee their products). Skin-eze does work on a high percentage of cases, though, and our rate of reorders is excellent. We wish we could help every animal, and we hope that the product works well for your pet. Our Customer Service representatives are available by email or telephone to help you to get the best results possible from our products.
    Q: My pet has lost a lot of hair from biting himself. What can I do for this?
    A: The Skin-eze Spray will help promote healing of the skin. In addition, our Vet Select Healthy Fresh food additive helps promote regrowth of damaged hair, in addition to many other health benefits. It contains enzymes and chelated minerals. Check the website for further info.
    Q: How long will it take before Skin-eze starts to work?
    A: Some pets respond to Skin-eze almost immediately. Other times, it takes longer. It takes diligence on the part of the owner to be sure to give Skin-eze twice daily, and to stick with it! Often times, best results are achieved when Skin-eze is used in combination with some of our topicals shampoo, O3 oil, and skin spray) especially if there is a lot of surface sores, red skin, ear problems, etc. In the more extreme cases, it might take as long as three to four weeks before you'll see a big improvement; however, even in these cases you should see some improvement within the first two or three weeks, with things getting progressively better from there. Remember to try increasing the dosage as necessary for good results, and don't be afraid of overdosing - Skin-eze is not a harmful drug that can cause unwanted side effects.
    Q: My pet got more itchy after starting on Skin-eze tabs. Is this possible?
    A: In rare cases, the pet could have an allergic reaction to one of the herbal ingredients. Also, if you have discontinued drug therapy within the previous month or two, your pet could become more itchy due to the side effects of stopping the drug therapy. In most cases, it is better to start using the Skin-eze products along with current therapies until your pet is 'itch free' for a week or two. Then slowly wean your pet off of the drug therapies (we suggest that you consult with the veterinarian who prescribed the drugs on how best to do this when your pet's condition has adequately improved).
    Q: Will Skin-eze help my itchy cat?
    A: Skin-eze works equally well on cats, and all of our topicals can be used on cats, also. We recommend Skin-eze tabs for cats. The best way to get cats to eat Skin-eze is to cut the tab into smaller pieces with a pill cutter and hide it in canned food or any of his favorite foods. The Skin-eze Spray will help promote healing of the skin. In addition, our Vet Select Healthy Fresh food additive helps promote regrowth of damaged hair, in addition to many other health benefits. It contains enzymes and chelated minerals. Check the website for further info.Skin-eze works equally well on cats, and all of our topicals can be used on cats, also. We recommend Skin-eze tabs for cats. The best way to get cats to eat Skin-eze is to cut the tab into smaller pieces with a pill cutter and hide it in canned food or any of his favorite foods. We also have our Cat Special Full Treatment Skin Pack which includes our liquid homeopathic skin formula for cats. Go to this link for more suggestions on administering Skin-eze tabs to cats: Directions
    Back to Top

    Skin-eze: How to Use Topical Products (Skin-eze Shampoo, Spray, and O3 Oil):

    Does your pet have any of these symptoms?

    1. 1
      History of ear problems (past or present)?
    2. 2
      Dry, flaky, skin with dandruff?
    3. 3
      Frequent licking of paws?
    4. 4
      Scabs or open sores?
    5. 5
      Nasty or foul odor (stinky ears, etc.)?
    6. 6
      Past history of above symptoms, but these symptoms subside when the dog is on steroids (prednisone, etc.), and come back soon after the steroids are discontinued?

    These cases will benefit by Skin-eze tabs or capsules. However, if your pet has any of the above symptoms, he may have a more extreme case that will require extra help. We recommend our Special Full Treatment Skin Pack for your pet, which includes our Skin-eze tabs or capsules, Skin-eze Magic Herbal Shampoo, Skin-eze Magic Herbal Skin Spray, and Skin-eze Healing O3 Oil. These products should be used as follows:

    1. 1
      Bathe daily with Skin-eze Magic Herbal Shampoo for first 3 or 4 (increase to up to 7 days if symptoms persist); if this is not possible due to size of pet, try spot bathing the affected areas). Bathe two times per week thereafter until the dog is completely itch free. Skin-eze Shampoo with conditioner is natural and safe to use daily, and will not dry the coat. Also, it works great as a whitener on discolored hair.
    2. 2
      If there is a problem with the ears, use Skin-eze Healing O3 Oil in ears (two drops 1-2 times daily as needed). Also, use Skin-eze shampoo around the outside of the ears when bathing. Skin-eze Magic Herbal skin spray can also be used - one spray in the ear and around the outside area of the ear (some pets do better with the O3 oil in the ears, while others do better using the Skin spray for the ears).
    3. 3
      Use Skin-eze Magic Herbal Skin Spray directly on any itchy area or hot spot in between bathing.
    4. 4
      Use Skin-eze Healing O3 Oil on any open sores on the body to help heal the skin and prevent infection.
    5. 5
      Use Skin-eze (capsules or tabs) two times daily. See Skin-eze suggested Dosage.

    Some pets will show improvement within the first 3 to 7 days. More extreme cases could take longer. It is not uncommon for us to hear comments like "I didn't think Skin-eze was working until about the third or fourth week, then my dog started to improve dramatically".